A new international expert consensus document refines and updates how heart failure is identified and classified, aiming to improve prevention, diagnosis and management of heart failure worldwide. According to estimates from global health data, more than 64 million adults globally currently have heart failure. Heart failure continues to increase in prevalence, driven in part by aging populations and rising rates of conditions that contribute to cardiovascular disease, such as obesity, Type 2 diabetes and high blood pressure.
The “Second Universal Definition of Heart Failure,” developed by leading cardiovascular organizations including the American Heart Association, the American College of Cardiology, the European Society of Cardiology and the World Heart Federation, in collaboration with the Heart Failure Society of America, the Heart Failure Association of the European Society of Cardiology and the Japanese Heart Failure Society, reaffirms and updates the First Universal Definition of Heart Failure, issued in 2021. The Second Definition details a consistent and comprehensive framework, emphasizing early detection and individualized risk reduction of heart failure, and introduces the universal classification of heart failure causes, with explicit acknowledgment of geographic variation in heart failure risk and outcomes. The consensus document simultaneously published today in the American Heart Association’s flagship peer-reviewed scientific journal Circulation; the American College of Cardiology’s flagship journal JACC; the European Society of Cardiology’s journal, the European Heart Journal; and the World Heart Federation’s journal, Global Heart.
“Heart failure remains a major challenge that continues to grow globally, and inconsistencies in how it is defined have limited progress in research and treatment,” said Mary Norine Walsh, M.D., co-chair of the consensus document for the American Heart Association and the American College of Cardiology, medical director of the heart failure program at Ascension St. Vincent Heart Center and medical director of the Ascension St. Vincent Cardiovascular Research Institute, both in Indianapolis. “This updated definition provides a clearer, more consistent framework to help clinicians identify risk earlier and guide more personalized treatment approaches that can help improve patient outcomes worldwide.”
The updated framework introduces several key changes that standardize terminology to align clinicians, researchers, health systems and policymakers. A universal classification of heart failure causes is introduced, helping with standardized reporting of data from trials and registries. This allows clinicians to better identify underlying conditions and guide targeted care beyond the current standard treatment for heart failure. The definition shifts away from rigid measurement thresholds for left ventricular ejection fraction (LVEF), instead taking into account differences by sex, age and ethnicity and offering clinically actionable categories: reduced, preserved and improved ejection fraction. Greater focus is placed on early stages of disease, emphasizing identification of people at risk or in early stages before symptoms appear to support prevention and earlier intervention. The condition is now described as dynamic, with potential for improvement, remission or progression. Finally, the document highlights how access to care, social drivers of health and geography affect heart failure risk and outcomes.
“The new framework recognizes that heart failure is not a static condition. By focusing on stages of disease, underlying causes and disease trajectories - including improvement, remission and recovery - we can better tailor care and advance prevention efforts,” Walsh said. The consensus document will serve as the foundation for the upcoming American Heart Association/American College of Cardiology Heart Failure Guideline, expected to publish in late 2027.
